Abstract | BACKGROUND: METHODS: Thirty-five patients with ACLF who had been subjected to intravenous administration of 600 mg linezolid every 12 hours for more than 7 days were categorized as a ACLF treatment (ACLF-T) group, 72 patients without ACLF treated with the same dosage of linezolid were recruited as a non-ACLF treatment (NACLF-T) group, and 70 patients with ACLF without linezolid treatment served as an ACLF control (ACLF-C) group. The incidences of thrombocytopenia in different groups were compared at day 14. Risk factors were investigated using logistic regression analysis. RESULTS: The incidence of thrombocytopenia at day 14 was significantly higher in the ACLF-T group than in the ACLF-C group (20/35 vs 24/70, P=0.025) and in the NACLF-T group (20/35 vs 9/72, P<0.001). Multivariate analysis showed that the ratio of platelet count (day 7/day 0)<1 (OR=10.021; P=0.012) and the baseline platelet count (OR=0.985; P=0.036) were independent risk factors of thrombocytopenia at day 14 of linezolid therapy. CONCLUSIONS:
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Authors | Yi-Min Zhang, Wei Yu, Ning Zhou, Jian-Zhou Li, Li-Chen Xu, Zhong-Yang Xie, Ying-Feng Lu, Lan-Juan Li |
Journal | Hepatobiliary & pancreatic diseases international : HBPD INT
(Hepatobiliary Pancreat Dis Int)
Vol. 14
Issue 3
Pg. 287-92
(Jun 2015)
ISSN: 1499-3872 [Print] Singapore |
PMID | 26063030
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Linezolid
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Topics |
- Acute-On-Chronic Liver Failure
(diagnosis, drug therapy)
- Administration, Intravenous
- Anti-Bacterial Agents
(administration & dosage, adverse effects)
- Chi-Square Distribution
- China
(epidemiology)
- Drug Administration Schedule
- Female
- Humans
- Incidence
- Linezolid
(administration & dosage, adverse effects)
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Odds Ratio
- Patient Selection
- Platelet Count
- Retrospective Studies
- Risk Factors
- Thrombocytopenia
(blood, chemically induced, diagnosis, epidemiology)
- Time Factors
- Treatment Outcome
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