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Initiating long-acting injectable antipsychotics during acute admission for patients with schizophrenia--A 3-year follow-up.

AbstractBACKGROUND/PURPOSE:
The debate on whether long-acting injectable antipsychotic (LAIA) medication is superior to oral medication, in preventing rehospitalization of patients with schizophrenia, remains inconclusive. We compared rehospitalization rates over 3 years following discharge from an acute admission, in which patients either began using LAIAs regularly for the first time, or continued to use oral antipsychotics.
METHODS:
A retrospective observational study of 92 inpatients with schizophrenia from a university-based medical center during 2004-2008. The primary outcome measure is the rehospitalization rates between groups, as estimated by Kaplan-Meier survival analysis.
RESULTS:
Eighteen of 47 (38.3%) LAIA patients, and 16 of 45 (35.6%) oral medication patients were rehospitalized (average time to rehospitalization, 378 ± 262 vs. 378 ± 340 days; p = 0.997). The estimated cumulative rates of rehospitalization were similar between groups. The overall odds comparing the LAIA to the oral medication group were 1.085 ± 0.373 (95% confidence interval: 0.553-2.13, p = 0.813). Compared to the oral medication group, the LAIA group had fewer coded with sufficient previous treatment response (32% vs. 69%, p < 0.001), more poorly compliant (91% vs. 56%, p < 0.001), and a slightly longer length of stay at index admission (32.7 ± 11.3vs. 27.6 ± 12.1, p = 0.04).
CONCLUSION:
Initiating LAIAs during admission for an acute psychotic episode, to a group of patients with an inadequate previous treatment response and poorer compliance, might keep their rehospitalization rates to the level of their oral antipsychotic medication treated counterparts.
AuthorsChen-Chung Liu, Jia-Chi Shan, Chih-Lin Chiang, Ming H Hsieh, Chih-Min Liu, Yi-Ling Chien, Shao-Chien Chen, Tzung-Jeng Hwang
JournalJournal of the Formosan Medical Association = Taiwan yi zhi (J Formos Med Assoc) Vol. 114 Issue 6 Pg. 539-45 (Jun 2015) ISSN: 0929-6646 [Print] Singapore
PMID26062967 (Publication Type: Comparative Study, Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013. Published by Elsevier B.V.
Chemical References
  • Antipsychotic Agents
Topics
  • Administration, Oral
  • Adult
  • Antipsychotic Agents (administration & dosage)
  • Female
  • Follow-Up Studies
  • Humans
  • Injections
  • Kaplan-Meier Estimate
  • Male
  • Medication Adherence
  • Middle Aged
  • Patient Readmission (statistics & numerical data)
  • Retrospective Studies
  • Schizophrenia (drug therapy)
  • Taiwan

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