Abstract | BACKGROUND/PURPOSE: METHODS: A retrospective observational study of 92 inpatients with schizophrenia from a university-based medical center during 2004-2008. The primary outcome measure is the rehospitalization rates between groups, as estimated by Kaplan-Meier survival analysis. RESULTS: Eighteen of 47 (38.3%) LAIA patients, and 16 of 45 (35.6%) oral medication patients were rehospitalized (average time to rehospitalization, 378 ± 262 vs. 378 ± 340 days; p = 0.997). The estimated cumulative rates of rehospitalization were similar between groups. The overall odds comparing the LAIA to the oral medication group were 1.085 ± 0.373 (95% confidence interval: 0.553-2.13, p = 0.813). Compared to the oral medication group, the LAIA group had fewer coded with sufficient previous treatment response (32% vs. 69%, p < 0.001), more poorly compliant (91% vs. 56%, p < 0.001), and a slightly longer length of stay at index admission (32.7 ± 11.3vs. 27.6 ± 12.1, p = 0.04). CONCLUSION: Initiating LAIAs during admission for an acute psychotic episode, to a group of patients with an inadequate previous treatment response and poorer compliance, might keep their rehospitalization rates to the level of their oral antipsychotic medication treated counterparts.
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Authors | Chen-Chung Liu, Jia-Chi Shan, Chih-Lin Chiang, Ming H Hsieh, Chih-Min Liu, Yi-Ling Chien, Shao-Chien Chen, Tzung-Jeng Hwang |
Journal | Journal of the Formosan Medical Association = Taiwan yi zhi
(J Formos Med Assoc)
Vol. 114
Issue 6
Pg. 539-45
(Jun 2015)
ISSN: 0929-6646 [Print] Singapore |
PMID | 26062967
(Publication Type: Comparative Study, Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013. Published by Elsevier B.V. |
Chemical References |
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Topics |
- Administration, Oral
- Adult
- Antipsychotic Agents
(administration & dosage)
- Female
- Follow-Up Studies
- Humans
- Injections
- Kaplan-Meier Estimate
- Male
- Medication Adherence
- Middle Aged
- Patient Readmission
(statistics & numerical data)
- Retrospective Studies
- Schizophrenia
(drug therapy)
- Taiwan
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