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Hispolon inhibits the growth of estrogen receptor positive human breast cancer cells through modulation of estrogen receptor alpha.

Abstract
Human estrogen receptor α (ERα) is a nuclear transcription factor that is a major therapeutic target in breast cancer. The transcriptional activity of ERα is regulated by certain estrogen-receptor modulators. Hispolon, isolated from Phellinus linteus, a traditional medicinal mushroom called Sanghwang in Korea, has been used to treat various pathologies, such as inflammation, gastroenteric disorders, lymphatic diseases, and cancers. In this latter context, Hispolon has been reported to exhibit therapeutic efficacy against various cancer cells, including melanoma, leukemia, hepatocarcinoma, bladder cancer, and gastric cancer cells. However, ERα regulation by Hispolon has not been reported. In this study, we investigated the effects of Hispolon on the growth of breast cancer cells. We found that Hispolon decreased expression of ERα at both mRNA and the protein levels in MCF7 and T47D human breast cancer cells. Luciferase reporter assays showed that Hispolon decreased the transcriptional activity of ERα. Hispolon treatment also inhibited expression of the ERα target gene pS2. We propose that Hispolon, an anticancer drug extracted from natural sources, inhibits cell growth through modulation of ERα in estrogen-positive breast cancer cells and is a candidate for use in human breast cancer chemotherapy.
AuthorsEun Hyang Jang, Soon Young Jang, In-Hye Cho, Darong Hong, Bom Jung, Min-Ju Park, Jong-Ho Kim
JournalBiochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 463 Issue 4 Pg. 917-22 (Aug 07 2015) ISSN: 1090-2104 [Electronic] United States
PMID26056942 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier Inc. All rights reserved.
Chemical References
  • Catechols
  • DNA Primers
  • Estrogen Receptor alpha
  • hispolon
Topics
  • Base Sequence
  • Breast Neoplasms (metabolism, pathology)
  • Catechols (pharmacology)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • DNA Primers
  • Estrogen Receptor alpha (drug effects, metabolism, physiology)
  • Female
  • Humans
  • Real-Time Polymerase Chain Reaction
  • Transcription, Genetic (physiology)

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