Abstract | BACKGROUND AND PURPOSE: METHODS: The study included 82 patients with MSA and 28 controls. Measures of total peripheral resistance were obtained during a head-up tilt test. Norepinephrine was administered to the patients lacking a vasoconstrictive response to evaluate its ability to treat orthostatic hypotension. RESULTS: At a 60° tilt, orthostatic hypotension occurred in 47.6% of the patients and 0% of controls. Reduction in total peripheral resistance from baseline at a 60° tilt was observed in 69.5% of the patients and 0% of controls. In patients with MSA, changes in systolic blood pressure from the baseline at a 60° tilt correlated positively with changes in the total peripheral resistance (r = 0.69, p < 0.0001). Norepinephrine prevented the reduction of total peripheral resistance and development of orthostatic hypotension. CONCLUSIONS:
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Authors | Junichiro Suzuki, Tomohiko Nakamura, Masaaki Hirayama, Yasuaki Mizutani, Akinori Okada, Mizuki Ito, Hirohisa Watanabe, Gen Sobue |
Journal | Parkinsonism & related disorders
(Parkinsonism Relat Disord)
Vol. 21
Issue 8
Pg. 917-22
(Aug 2015)
ISSN: 1873-5126 [Electronic] England |
PMID | 26054882
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. |
Chemical References |
- Vasoconstrictor Agents
- Norepinephrine
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Topics |
- Aged
- Autonomic Nervous System Diseases
(drug therapy, etiology, physiopathology)
- Female
- Humans
- Hypotension, Orthostatic
(drug therapy, etiology, physiopathology)
- Male
- Middle Aged
- Multiple System Atrophy
(complications)
- Norepinephrine
(administration & dosage, pharmacology)
- Treatment Outcome
- Vasoconstrictor Agents
(administration & dosage, pharmacology)
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