In vivo evaluation of hydrophobic and fibrillar microporous polyetherurethane urea graft.

Abstract

Mitrathane hydrophobic and fibrillar microporous prosthesis was implanted as infrarenal arterial substitute in dogs; it was evaluated in terms of patency rates, healing characteristics and biostability. Segments of grafts were implanted in duplicate for a period of implantation of 24 h, 1 wk, 1 month and 6 month. Two control grafts from the Ontario Research Foundation were implanted: one for 1 month, the other for six month. All except the two Mitrathane grafts implanted for 6 month were patent at death. The Mitrathane grafts showed kinking at one and 6 month post-implantation. The ORF graft implanted for 1 month was found crinkled in its mid-section and the external capsule was ruptured in the graft implanted for 6 month, without crinkling. Histological studies showed fibrin deposits on the flow surface and infiltration of blood elements into the wall of the Mitrathane grafts implanted for 24 h and 1 wk. A thin internal capsule was present on the graft flow surface of both types of graft tested 1 month post-implantation; scanning electron microscopy revealed the presence of endothelial-like cells on the luminal surface, particularly in the vicinity of the anastomoses. At 6 month, the Mitrathane grafts were occluded by a thick thrombus originating from the anastomoses, while the ORF graft showed infiltration of collagen through the polyurethane fibrillar structure of the wall with an endothelial-like lining covering the flow surface in the vicinity of both anastomoses.

• Authors: Y Marois, R Guidoin, D Boyer, F Assayed, C J Doillon, R Paynter, M Marois
• Journal: Biomaterials (Biomaterials) Vol. 10 Issue 8 Pg. 521-31 (Oct 1989) ISSN: 0142-9612 [Print] Netherlands
• PMID: 2605286 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biocompatible Materials
• Polymers
• Polyurethanes
• polyetherurethane urea

Topics

• Animals
• Aorta (surgery)
• Biocompatible Materials
• Blood Cells (pathology)
• Blood Vessel Prosthesis
• Dogs
• Female
• Graft Occlusion, Vascular (pathology)
• Male
• Microscopy, Electron, Scanning
• Polymers
• Polyurethanes
• Prosthesis Design
• Surface Properties
• Thrombosis (pathology)
• Vascular Patency