Abstract | BACKGROUND: MATERIALS AND METHODS: RESULTS: Compared with waitlisted adult HUS patients on dialysis, 5-year mortality risks were 73% and 48% lower in recipients of living (hazard ratio [HR], 0.27, 95% confidence interval [95% CI], 0.11-0.65) and standard deceased (HR, 0.52; 95% CI, 0.29-0.94) donor kidney transplants, respectively. Mortality risks over 5 years were 44%, 50%, 54%, and 55% lower in the overall transplant recipient cohorts than in the dialysis-maintained cohorts within the HUS (HR, 0.56; 95% CI, 0.35-0.91), HTN (HR, 0.50; 95% CI, 0.48-0.52), GN (HR, 0.46; 95% CI, 0.44-0.49), and DM (HR, 0.45; 95% CI, 0.44-0.47) groups, respectively. Five-year transplantation probability in the waitlisted HUS cohort was 60% versus 42% to 49% (P < 0.001) in the DM and HTN cohorts, and 62% (P = 0.93) in the GN cohort. CONCLUSIONS: Living and standard criteria deceased donor kidney transplants provide significant survival benefit over dialysis in waitlisted adults with HUS. On the waitlist, the 5-year transplantation probability was higher in HUS than in DM and HTN patients.
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Authors | Alfonso H Santos Jr, Michael J Casey, Xuerong Wen, Ivan Zendejas, Shehzad Rehman, Karl L Womer, Kenneth A Andreoni |
Journal | Transplantation
(Transplantation)
Vol. 99
Issue 12
Pg. 2608-16
(Dec 2015)
ISSN: 1534-6080 [Electronic] United States |
PMID | 26050014
(Publication Type: Journal Article, Observational Study)
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Topics |
- Adult
- Female
- Florida
(epidemiology)
- Forecasting
- Hemolytic-Uremic Syndrome
(mortality, therapy)
- Humans
- Kidney Transplantation
(mortality)
- Male
- Middle Aged
- Registries
- Renal Dialysis
- Retrospective Studies
- Risk Factors
- Survival Rate
(trends)
- Transplant Recipients
- Waiting Lists
(mortality)
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