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Deciphering the BRCA1 Tumor Suppressor Network.

Abstract
The BRCA1 tumor suppressor protein is a central constituent of several distinct macromolecular protein complexes that execute homology-directed DNA damage repair and cell cycle checkpoints. Recent years have borne witness to an exciting phase of discovery at the basic molecular level for how this network of DNA repair proteins acts to maintain genome stability and suppress cancer. The clinical dividends of this investment are now being realized with the approval of first-in-class BRCA-targeted therapies for ovarian cancer and identification of molecular events that determine responsiveness to these agents. Further delineation of the basic science underlying BRCA network function holds promise to maximally exploit genome instability for hereditary and sporadic cancer therapy.
AuthorsQinqin Jiang, Roger A Greenberg
JournalThe Journal of biological chemistry (J Biol Chem) Vol. 290 Issue 29 Pg. 17724-17732 (Jul 17 2015) ISSN: 1083-351X [Electronic] United States
PMID26048987 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Copyright© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
Chemical References
  • BRCA1 Protein
Topics
  • Animals
  • BRCA1 Protein (analysis, genetics, metabolism)
  • Breast (metabolism, pathology)
  • Breast Neoplasms (genetics, metabolism, pathology, therapy)
  • DNA Damage
  • DNA Repair
  • Female
  • Genomic Instability
  • Humans
  • Molecular Targeted Therapy
  • Ovarian Neoplasms (genetics, metabolism, pathology, therapy)
  • Ovary (metabolism, pathology)
  • Protein Interaction Maps

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