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Intestinal fucose as a mediator of host-microbe symbiosis.

Abstract
Fucose is an L-configuration sugar found abundantly in the mammalian gut. It has long been known to be induced there by the presence of bacteria, but only recently have some of the molecular mechanisms behind this process been uncovered. New work suggests that fucose can have a protective role in both gut-centered and systemic infection and inflammation. This review highlights recent studies showing that, in addition to acting as a food source for beneficial gut symbionts, host fucose can suppress the virulence of pathogens and pathobionts. The relevance of gut fucosylation to human diseases also is discussed.
AuthorsJoseph M Pickard, Alexander V Chervonsky
JournalJournal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 194 Issue 12 Pg. 5588-93 (Jun 15 2015) ISSN: 1550-6606 [Electronic] United States
PMID26048966 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2015 by The American Association of Immunologists, Inc.
Chemical References
  • Fucose
Topics
  • Animals
  • Fucose (metabolism)
  • Host-Pathogen Interactions
  • Humans
  • Intestinal Mucosa (metabolism)
  • Intestines (microbiology)
  • Microbiota
  • Symbiosis

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