Abstract | PURPOSE: METHODS:
5-FU was administered to rats orally once daily, and ED was supplied orally twice daily for 5 days. The severity of mucositis was assessed by length, dry tissue weight, and villus height of the intestinal tract. Using anti- mucin monoclonal antibody, we compared the immunoreactivity in the gastrointestinal (GI) tract and mucin content by histological and biochemical examinations. RESULTS: Oral supplementation with ED reduced histological damage and loss of length, dry tissue weight, and villus height induced by 5-FU administration. ED markedly altered PGM34 antibody immunoreactivity and mucin contents in the small intestine of rats with 5-FU-induced mucositis. CONCLUSIONS:
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Authors | Rei Kawashima, Fumitaka Kawakami, Tatsunori Maekawa, Hajime Yamamoto, Wasaburo Koizumi, Takafumi Ichikawa |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 76
Issue 2
Pg. 269-77
(Aug 2015)
ISSN: 1432-0843 [Electronic] Germany |
PMID | 26048344
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Fluorouracil
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Topics |
- Animals
- Antineoplastic Agents
(adverse effects)
- Fluorouracil
(adverse effects)
- Food, Formulated
- Gastrointestinal Tract
(drug effects, metabolism, physiopathology)
- Male
- Mucositis
(chemically induced, diet therapy, physiopathology)
- Mucus
(metabolism)
- Rats, Wistar
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