Compatibility and stability of the
polygeline-based blood plasma expander/plasma substitute
Haemaccel with different
drug products i.e.,
Profenid, Stemetil, and
Lasix were examined in the context of its potential use in surgical, spinal,
septic shock and in circulatory insufficiency, because treatment, safety, acceptability and efficacy of
drug product may be affected by
drug instability or incompatibility. Therefore,
drug stability and compatibility are critical elements in accurate and appropriate delivery of
drug therapy to patients. This study was initiated to specifically and critically assess the compatibility of
Haemaccel with different
drug products with the aim of delivering safe, suitable, acceptable and efficacious administration of two different
drug products simultaneously in emergency conditions. All of these different brands of
drug products were physically and chemically compatible with
Haemaccel and all of the test results were almost similar before and after mixing different drugs in
Haemaccel. This study revealed that
Lasix,
Profenid and Stemetil can be administered/co-administered with
Haemaccel safely. Different
drug product must be studies in detail before it's co-administration with
Haemaccel.