Pulse cyclophosphamide therapy in the management of patients with macular serpiginous choroidopathy.

Abstract

PURPOSE:

To evaluate safety and efficacy of intravenous pulse cyclophosphamide (CyP) in acute macular serpiginous choroiditis (SC).

METHODS:

Patients with acute macular SC with lesions threatening and/or involving fovea were enrolled. All patients received CyP (1 g/m2) for 3 days followed by high-dose oral steroids (1.5 mg/kg) tapered over 6 months and monitored for visual acuity, response to treatment and systemic side effects.

RESULTS:

Eight patients (seven unilateral and one bilateral) with median age of 27 years (range: 13-40 years) were recruited. Mean visual acuity at presentation was 0.71 ± 0.35 logarithm of the minimum angle of resolution while postpulse visual acuity was 0.40 ± 0.32. Final mean visual acuity at 1-year was 0.31 ± 0.23 (P ≤ 0.05). Three eyes had recurrence and 3 patients developed transient hair loss with no other adverse effect.

CONCLUSION:

Intravenous CyP provides rapid resolution of lesion activity and thereby helps in maintaining good functional acuity.

• Authors: Pradeep Venkatesh, Varun Gogia, Shikha Gupta, Akshay Tayade, Neha Shilpy, Bhavin M Shah, Randeep Guleria
• Journal: Indian journal of ophthalmology (Indian J Ophthalmol) Vol. 63 Issue 4 Pg. 318-22 (Apr 2015) ISSN: 1998-3689 [Electronic] India
• PMID: 26044470 (Publication Type: Journal Article)

Chemical References

• Immunosuppressive Agents
• Cyclophosphamide

Topics

• Adolescent
• Adult
• Choroiditis (diagnosis, drug therapy, physiopathology)
• Cyclophosphamide (administration & dosage)
• Female
• Fluorescein Angiography
• Follow-Up Studies
• Fundus Oculi
• Humans
• Immunosuppressive Agents (administration & dosage)
• Infusions, Intravenous
• Macula Lutea (pathology)
• Male
• Multifocal Choroiditis
• Retrospective Studies
• Treatment Outcome
• Visual Acuity
• Young Adult