Abstract | BACKGROUND: METHODS: This study aimed to determine the frequency of expression of Rb1, P16 and ER in ovarian epithelial tumors by immunohistochemistry. RESULTS: Co-expression of all 3 markers studied was seen in 10% of high grade serous carcinoma (HGSC) and low grade serous carcinoma (LGSC). Coordinate expression of Rb1+ and ER+ in HGSC and LGSC was seen in 67% of grade 1/2 vs. 44 % of grade three tumors (p < 0.05). The reverse was true with positive P16 staining in 73% of grade three vs. 32% of grade 1/2 tumors (p < 0.001). CONCLUSIONS: Coordinate pattern of Rb1+ and ER+ in HGSC and LGSC is 19 and 50%, respectively. Rb1 and P16 show inverse expression pattern according to tumor grade with more frequent Rb1 in low grade vs. more frequent P16 in grade 3 tumors. These data provide a rational basis for clinical trials that aim to target these proteins.
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Authors | Donna Catherine Ferguson, Daniel Jerad Long, Megan Christine Smith, Laura Deeanne Craig-Owens, Julie Means, Oluwole Fadare, Mohamed Mokhtar Desouki |
Journal | Journal of ovarian research
(J Ovarian Res)
Vol. 8
Pg. 34
(Jun 05 2015)
ISSN: 1757-2215 [Electronic] England |
PMID | 26043844
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Cyclin-Dependent Kinase Inhibitor p16
- ESR1 protein, human
- Estrogen Receptor alpha
- Retinoblastoma Protein
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Topics |
- Biomarkers, Tumor
(biosynthesis, genetics)
- Carcinoma, Ovarian Epithelial
- Cyclin-Dependent Kinase Inhibitor p16
(biosynthesis, genetics)
- Estrogen Receptor alpha
(biosynthesis, genetics)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Neoplasm Staging
- Neoplasms, Glandular and Epithelial
(genetics, pathology)
- Ovarian Neoplasms
(genetics, pathology)
- Prognosis
- Retinoblastoma Protein
(biosynthesis, genetics)
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