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Comparative analysis of Rb1, P16 and ER as diagnostic, prognostic and potential targets for therapeutic agents in ovarian epithelial tumors: an immunohistochemical study of 130 ovarian carcinomas.

AbstractBACKGROUND:
Deregulation of CDK4/6, cyclin D/P16 and retinoblastoma (Rb) are known aberrations in certain malignancies. There has been a recent interest in exploring the combination of letrozole and CDK4/6 inhibitors in recurrent ER+ ovarian cancers.
METHODS:
This study aimed to determine the frequency of expression of Rb1, P16 and ER in ovarian epithelial tumors by immunohistochemistry.
RESULTS:
Co-expression of all 3 markers studied was seen in 10% of high grade serous carcinoma (HGSC) and low grade serous carcinoma (LGSC). Coordinate expression of Rb1+ and ER+ in HGSC and LGSC was seen in 67% of grade 1/2 vs. 44 % of grade three tumors (p < 0.05). The reverse was true with positive P16 staining in 73% of grade three vs. 32% of grade 1/2 tumors (p < 0.001).
CONCLUSIONS:
Coordinate pattern of Rb1+ and ER+ in HGSC and LGSC is 19 and 50%, respectively. Rb1 and P16 show inverse expression pattern according to tumor grade with more frequent Rb1 in low grade vs. more frequent P16 in grade 3 tumors. These data provide a rational basis for clinical trials that aim to target these proteins.
AuthorsDonna Catherine Ferguson, Daniel Jerad Long, Megan Christine Smith, Laura Deeanne Craig-Owens, Julie Means, Oluwole Fadare, Mohamed Mokhtar Desouki
JournalJournal of ovarian research (J Ovarian Res) Vol. 8 Pg. 34 (Jun 05 2015) ISSN: 1757-2215 [Electronic] England
PMID26043844 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers, Tumor
  • Cyclin-Dependent Kinase Inhibitor p16
  • ESR1 protein, human
  • Estrogen Receptor alpha
  • Retinoblastoma Protein
Topics
  • Biomarkers, Tumor (biosynthesis, genetics)
  • Carcinoma, Ovarian Epithelial
  • Cyclin-Dependent Kinase Inhibitor p16 (biosynthesis, genetics)
  • Estrogen Receptor alpha (biosynthesis, genetics)
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Neoplasm Staging
  • Neoplasms, Glandular and Epithelial (genetics, pathology)
  • Ovarian Neoplasms (genetics, pathology)
  • Prognosis
  • Retinoblastoma Protein (biosynthesis, genetics)

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