Role of the tumor necrosis factor family member LIGHT in the pathogenesis of atopic dermatitis.

Abstract

BACKGROUND:

LIGHT (the name of which is derived from "homologous to lymphotoxins, exhibits inducible expression, competes with herpes simplex virus glycoprotein D for herpes simplex virus entry mediator, and expressed by T lymphocytes"), is a member of the tumor necrosis factor superfamily that is involved in various inflammatory diseases.

OBJECTIVES:

To assess serum LIGHT levels in patients with atopic dermatitis (AD) before and after treatment and compare it with controls. To correlate serum LIGHT with the severity scoring of AD (SCORAD) index. Another objective is to compare LIGHT levels between lesional skin in patients with AD and controls.

METHODS:

Twenty patients with AD and 20 healthy controls were enrolled in the study. Serum LIGHT levels were examined using an enzyme immunoassay technique. Serum total IgE levels, absolute eosinophil count, and eosinophil percentage were also done for both patients and controls. The SCORAD index was done for every patient before and after treatment. Skin LIGHT levels were analyzed using enzyme-linked immunosorbent assay kit and compared with control skin.

RESULTS:

Serum LIGHT levels in patients with AD were significantly higher than that of healthy controls and correlated positively with SCORAD index. LIGHT concentrations decreased as the symptoms were improved by treatment. A significant correlation was found on comparing the LIGHT serum levels and other established markers of disease severity. LIGHT levels in lesional skin in these patients were markedly higher than LIGHT levels in normal skin.

CONCLUSION:

LIGHT may play an important role in the pathogenesis of AD. This may presumably have possible future implications on the treatment of this chronic disease.

• Authors: Neveen Salah Seifeldin, Shereen Bendary El Sayed, Marwa Kamal Asaad, Alaa Ahmed Aly
• Journal: International journal of dermatology (Int J Dermatol) Vol. 54 Issue 10 Pg. e376-82 (Oct 2015) ISSN: 1365-4632 [Electronic] England
• PMID: 26043794 (Publication Type: Journal Article)
• Copyright: © 2015 The International Society of Dermatology.

Chemical References

• Histamine Antagonists
• Steroids
• Tumor Necrosis Factor Ligand Superfamily Member 14
• Immunoglobulin E

Topics

• Adolescent
• Adult
• Case-Control Studies
• Dermatitis, Atopic (blood, drug therapy, metabolism)
• Eosinophils
• Female
• Histamine Antagonists (therapeutic use)
• Humans
• Immunoglobulin E (blood)
• Leukocyte Count
• Male
• Severity of Illness Index
• Skin (metabolism)
• Steroids (therapeutic use)
• Tumor Necrosis Factor Ligand Superfamily Member 14 (blood, metabolism)
• Young Adult