Abstract | BACKGROUND: METHODS: A prospective, cross-sectional study was conducted between January 2009 and January 2013 in which 896 Roux-en-Y gastric bypasses were performed to treat obesity. The study compared three groups of patients according to the perioperative antibiotic prophylaxis administered intravenously and beginning at anesthesia induction: Group I consisting of 194 patients treated with two 3-g doses of ampicillin/sulbactam; Group II with 303 patients treated with a single 1-g dose of ertapenem; and Group III with 399 patients treated with a 2-g dose of cefazolin at anesthesia induction followed by a continuous infusion of cefazolin 1g throughout the surgical procedure. The rate of surgical site infection was analyzed, as well as its association with age, sex, preoperative weight, body mass index and comorbidities. RESULTS: CONCLUSION: The prophylactic use of continuous cefazolin in surgeries for morbid obesity shows very promising results. These findings suggest that some prophylactic regimens need to be reconsidered and even substituted by more effective therapies for the prevention of surgical site infections in bariatric patients.
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Authors | Álvaro Antônio Bandeira Ferraz, Luciana Teixeira de Siqueira, Josemberg Marins Campos, Guido Correa de Araújo, Euclides Dias Martins Filho, Edmundo Machado Ferraz |
Journal | Arquivos de gastroenterologia
(Arq Gastroenterol)
2015 Apr-Jun
Vol. 52
Issue 2
Pg. 83-7
ISSN: 1678-4219 [Electronic] Brazil |
PMID | 26039823
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- beta-Lactams
- Ampicillin
- Ertapenem
- Cefazolin
- Sulbactam
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Topics |
- Adolescent
- Adult
- Aged
- Ampicillin
(administration & dosage)
- Anti-Bacterial Agents
(administration & dosage)
- Antibiotic Prophylaxis
(methods)
- Cefazolin
(administration & dosage)
- Cross-Sectional Studies
- Drug Therapy, Combination
- Ertapenem
- Female
- Gastric Bypass
(adverse effects, methods)
- Humans
- Infusions, Intravenous
- Male
- Middle Aged
- Prospective Studies
- Sulbactam
(administration & dosage)
- Surgical Wound Infection
(prevention & control)
- Young Adult
- beta-Lactams
(administration & dosage)
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