[Panton-Valentine leukocidin-positive osteoarticular infections].

Abstract

OBJECTIVES:

The aim of our study was to evaluate the frequency of osteoarticular infections with Panton-Valentine leukocidin-positive (PVL) Staphylococcus aureus (PVL-SA) among patients admitted to the orthopedic ward at the Sahloul University Hospital (Sousse, Tunisia) and to study the characteristics of these strains and patients.

MATERIALS AND METHODS:

We conducted a retrospective descriptive study over a 5-year period. Bacterial identification, antibiotic susceptibility, and molecular study (PCR to detect of the luk-PV gene that encodes PVL) were performed for 44 S. aureus isolates.

RESULTS:

Panton-Valentine toxin was found in 41% of S. aureus cases, mainly males, and 39% of the PVL(+) cases were methicillin-sensitive (MSSA). These strains constitute a reservoir of PVL genes that can lead to the emergence and spread of PVL-SA clones resistant to methicillin (MRSA). In our series, PVL-MRSA accounted for 9% of all S. aureus isolates. Their profile and antibiotic resistance is that of clone ST80, frequently isolated in Europe and also reported in Algeria and Tunisia.

CONCLUSION:

It is desirable to test for PVL routinely in the laboratory to implement appropriate treatment and to monitor the epidemiology of these PVL-SA strains actively. Further measures should be undertaken to prevent and fight infections by these strains.

• Authors: C Chaouch, S Kacem, L Tilouche, S Ketata, O Bouallegue, N Boujaafar
• Journal: Medecine et sante tropicales (Med Sante Trop) 2015 Apr-Jun Vol. 25 Issue 2 Pg. 184-8 ISSN: 2261-2211 [Electronic] France
• Vernacular Title: Infections ostéoarticulaires à Staphylococcus aureus portant le gène de la leucocidine de Panton-Valentine.
• PMID: 26039246 (Publication Type: English Abstract, Journal Article)

Chemical References

• Bacterial Toxins
• Exotoxins
• Leukocidins
• Panton-Valentine leukocidin

Topics

• Adolescent
• Adult
• Bacterial Toxins (biosynthesis)
• Bone Diseases, Infectious (microbiology)
• Child
• Child, Preschool
• Exotoxins (biosynthesis)
• Female
• Humans
• Infant
• Joint Diseases (microbiology)
• Leukocidins (biosynthesis)
• Male
• Middle Aged
• Retrospective Studies
• Staphylococcal Infections (microbiology)
• Staphylococcus aureus (metabolism)
• Tunisia
• Young Adult