Axitinib: from preclinical development to future clinical perspectives in renal cell carcinoma.

Abstract

INTRODUCTION:

Based on extensive preclinical data and abundant evidence for clinical activity, vascular endothelial growth factor receptor (VEGFR) inhibitors are currently standard of care for metastatic renal cell carcinoma (mRCC). Axitinib is one of the most selective molecules in the class of anti-angiogenic agents, which confers an optimal profile between its safety and anti-cancer activity spectrum.

AREA COVERED:

In this review, the authors discuss the different stages that lead to the approval of axitinib in the clinic as well as the current perspectives for its clinical use with other promising therapies in mRCC such as immune checkpoint inhibitors and vaccines.

EXPERT OPINION:

In 2015, axitinib has emerged as one of the major agents used in mRCC. Based on robust preclinical data, this highly specific VEGFR inhibitor continues to be evaluated in different indications, including the adjuvant setting but also sequential administration with other molecularly targeted agents or combinations with immune therapies.

• Authors: Yousef Zakharia, Kais Zakharia, Olivier Rixe
• Journal: Expert opinion on drug discovery (Expert Opin Drug Discov) Vol. 10 Issue 8 Pg. 925-35 ( 2015) ISSN: 1746-045X [Electronic] England
• PMID: 26039031 (Publication Type: Journal Article, Review)

Chemical References

• Angiogenesis Inhibitors
• Antineoplastic Agents
• Imidazoles
• Indazoles
• Protein Kinase Inhibitors
• Axitinib
• Receptors, Vascular Endothelial Growth Factor

Topics

• Angiogenesis Inhibitors (adverse effects, pharmacology, therapeutic use)
• Animals
• Antineoplastic Agents (adverse effects, pharmacology, therapeutic use)
• Axitinib
• Carcinoma, Renal Cell (drug therapy, pathology)
• Humans
• Imidazoles (adverse effects, pharmacology, therapeutic use)
• Indazoles (adverse effects, pharmacology, therapeutic use)
• Kidney Neoplasms (drug therapy, pathology)
• Protein Kinase Inhibitors (adverse effects, pharmacology, therapeutic use)
• Receptors, Vascular Endothelial Growth Factor (antagonists & inhibitors)