MANAGEMENT OF ENDOCRINE DISEASE: Paediatric Cushing's disease.

Abstract

Cushing's disease (CD) is the commonest form of ACTH-dependent Cushing's syndrome and is a rare clinical diagnosis in paediatric and adolescent patients. CD is caused by an ACTH-secreting pituitary corticotroph adenoma and is associated with significant morbidity in children; therefore, early diagnosis and treatment are critical for optimal therapeutic outcome. This review highlights the key clinical and biochemical features of paediatric CD and appraises current practices in diagnosis and management. A close liaison with adult endocrinology colleagues, particularly, for interpretation of investigations and definition of therapeutic strategy is strongly advised.

• Authors: Helen L Storr, Martin O Savage
• Journal: European journal of endocrinology (Eur J Endocrinol) Vol. 173 Issue 1 Pg. R35-45 (Jul 2015) ISSN: 1479-683X [Electronic] England
• PMID: 26036813 (Publication Type: Journal Article, Review)
• Copyright: © 2015 European Society of Endocrinology.

Topics

• Adolescent
• Adrenalectomy
• Child
• Child, Preschool
• Humans
• Pituitary ACTH Hypersecretion (diagnosis, epidemiology, surgery, therapy)
• Pituitary Gland (surgery)