[Antioxidant properties of cluster rhenium compounds and their effect on erythropoiesis of rats with guerin carcinoma].

Abstract

Biochemical characteristics of kidneys, pe- ripheral blood and bone marrow of rats in model of tumor growth under introduction of cisplatin and cis-tetrachlorodi-μ-isobutyratodirhenium(III), cis-Re2(i-C3H7COO)2Cl4 (I) have been investigated. It was shown that introduction of I alone and together with cisplatin led to decrease of biochemical markers of oxidation of lipids and proteins in tissue homogenates of the kidneys, change of enzyme activity in the urea and tissue homogenates of the kidneys, by a decrease of filtration function of kidneys. Introduction of nanoliposomal forms of the rhenium cluster compound led to a practically normal morphological picture of bone marrow and increase of the RBC (by 60%) with normalization of hematocrit counts, and decrease of quantities of destructed RBC (3.2 times) in comparison with the tumor-bearing animals. A tentative scheme of influence of cluster rhenium compound on erythropoiesis through regulation of synthesis of erythropoietin in kidneys has been proposed.

• Authors: Y S Voronkova, S O Babiy, L V Ivans'kar, O V Shtemenko, N I Shtemenko
• Journal: Ukrainian biochemical journal (Ukr Biochem J) 2015 Jan-Feb Vol. 87 Issue 1 Pg. 99-108 ISSN: 2409-4943 [Print] Ukraine
• PMID: 26036136 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Antioxidants
• Coordination Complexes
• Erythropoietin
• Rhenium
• Cisplatin

Topics

• Animals
• Antineoplastic Agents (administration & dosage, toxicity)
• Antioxidants (chemical synthesis, pharmacology)
• Bone Marrow (drug effects, pathology)
• Carcinoma (drug therapy, pathology, urine)
• Cisplatin (administration & dosage, toxicity)
• Coordination Complexes (chemical synthesis, pharmacology)
• Erythrocyte Count
• Erythrocytes (drug effects)
• Erythropoiesis (drug effects)
• Erythropoietin (agonists, biosynthesis)
• Hematocrit
• Kidney (drug effects, metabolism, pathology)
• Kidney Neoplasms (drug therapy, pathology, urine)
• Rats
• Rats, Wistar
• Rhenium (chemistry, pharmacology)