Recurrent myocardial infarction secondary to Prinzmetal's variant angina.

Abstract

Prinzmetal's variant angina describes chest pain secondary to reversible coronary artery vasospasm in the context of both diseased and non-diseased coronary arteries. Symptoms typically occur when the patient is at rest and are associated with transient ST-segment elevation. Acute episodes respond to glyceryl trinitrate, but myocardial infarction and other potentially fatal complications can occur, and long-term management can be challenging. Although it is not well understood, the underlying mechanism appears to involve a combination of endothelial damage and vasoactive mediators. In this case, a 35-year-old woman with myocardial infarction secondary to coronary artery vasospasm experienced recurrent chest pain. Coronary angiography revealed severe focal stenosis in the mid left anterior descending artery, which completely resolved after administration of intracoronary glyceryl trinitrate. The patient was discharged on nitrates and calcium channel blockers. The patient re-presented with another myocardial infarction, requiring up-titration of medical therapy.

• Authors: Dale Murdoch, Priyanka Dhillon, Selvanayagam Niranjan
• Journal: Singapore medical journal (Singapore Med J) Vol. 56 Issue 5 Pg. e74-7 (May 2015) ISSN: 0037-5675 [Print] India
• PMID: 26034323 (Publication Type: Case Reports, Journal Article)

Chemical References

• Vasodilator Agents
• Nitroglycerin

Topics

• Adult
• Angina Pectoris, Variant (complications, drug therapy)
• Constriction, Pathologic (drug therapy, pathology)
• Coronary Angiography
• Coronary Vasospasm
• Coronary Vessels (physiopathology)
• Electrocardiography
• Female
• Humans
• Myocardial Infarction (complications, drug therapy, pathology)
• Nitroglycerin (therapeutic use)
• Recurrence
• Vasodilator Agents (therapeutic use)