Update on the role of Interleukin 17 in rheumatologic autoimmune diseases.

Abstract

Interleukin 17 is a proinflammatory cytokine produced by CD4+ T cells when in the presence of a distinct set of cytokines and other cells. Preclinical and clinical studies have assigned a role to IL-17 in tissue inflammation and damage in patients with rheumatoid arthritis, psoriasis and psoriatic arthritis, ankylosing spondylitis and systemic lupus erythematosus. Antibodies blocking the action of IL-17 have already been approved to treat patients with psoriasis and it is expected that they may also benefit patients with other rheumatic diseases.

• Authors: Christine Konya, Ziv Paz, Sokratis A Apostolidis, George C Tsokos
• Journal: Cytokine (Cytokine) Vol. 75 Issue 2 Pg. 207-15 (Oct 2015) ISSN: 1096-0023 [Electronic] England
• PMID: 26028353 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Interleukin-17

Topics

• Arthritis, Psoriatic (drug therapy, immunology)
• Arthritis, Rheumatoid (drug therapy, immunology)
• Autoimmune Diseases (drug therapy, immunology)
• CD4-Positive T-Lymphocytes (immunology)
• Humans
• Inflammation (immunology)
• Interleukin-17 (antagonists & inhibitors, immunology)
• Lupus Erythematosus, Systemic (drug therapy, immunology)
• Signal Transduction (immunology)
• Spondylitis, Ankylosing (drug therapy, immunology)