Abstract | BACKGROUND: Abnormal catenin expression has been related to mammary carcinogenesis in both human and canine species and they are considered tumor- and invasion-suppressor molecules; however, in feline mammary tissues they have been scarcely studied. MATERIALS AND METHODS: The immunohistochemical expression of α-, β- and p120-catenin was studied in a series of normal feline mammary glands, hyperplastic/dysplastic lesions and benign and malignant mammary tumors. Their relationship with clinicopathological parameters and with E- and P-cadherin expression was assessed. RESULTS: Normal tissues, hyperplastic/dysplastic lesions and benign tumors expressed α-, β- and p120-catenin in the membrane of more than 75% of the luminal epithelial cells, while in malignant tumors, there was a reduction in their membranous expression and a p120-catenin cytoplasmic expression in 40%. Reduced α- catenin expression was related to tumor features with prognostic value, namely tumor size (p=0.0203) and necrosis (p=0.0205). The expression of α-, β- and p120-catenin were individually related to each other and collectively associated with E-cadherin expression. CONCLUSION: The results demonstrate a relationship between feline mammary carcinogenesis and decreased expression of catenins, suggesting that they may represent a valuable tool in the diagnosis of feline mammary neoplasms.
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Authors | Ana Catarina Figueira, Catarina Gomes, Hugo Vilhena, Sónia Miranda, Júlio Carvalheira, Augusto J F DE Matos, Patrícia Dias-Pereira, Fátima Gärtner |
Journal | Anticancer research
(Anticancer Res)
Vol. 35
Issue 6
Pg. 3361-9
(Jun 2015)
ISSN: 1791-7530 [Electronic] Greece |
PMID | 26026096
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- Cadherins
- Catenins
- alpha Catenin
- beta Catenin
- Delta Catenin
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Topics |
- Animals
- Biomarkers, Tumor
(biosynthesis)
- Breast Neoplasms
(genetics, pathology, veterinary)
- Cadherins
(biosynthesis)
- Carcinogenesis
(genetics)
- Catenins
(biosynthesis)
- Cats
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- Mammary Glands, Animal
(metabolism, pathology)
- alpha Catenin
(biosynthesis)
- beta Catenin
(biosynthesis)
- Delta Catenin
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