Differential genomic damage in different tumor lines induced by prodigiosin.

Abstract

Prodigiosin is a secondary metabolite produced by Serratia marcercens. As this pigment is suggested to be a cancer drug, genotoxicity studies are necessary. The aim of the present investigation was to evaluate the genotoxic effects of prodigiosin on tumoral and normal cell lines, NCIH-292, MCF-7 and HL-60. A normal line BGMK was used as control. Genomic damage induced by prodigiosin was observed in all tumor lines as well as the control line. The pigment induced the formation of micronuclei in tumor cells. The present data confirm the antitumor potential of prodigiosin. However, these findings also raise concerns regarding its target-specific action, as genotoxic effects on normal cells also occurred.

• Authors: Jeanne Cristina Lapenda Lins, Maria Eliane Bezerra DE Melo, Silene Carneiro DO Nascimento, Monica Lucia Adam
• Journal: Anticancer research (Anticancer Res) Vol. 35 Issue 6 Pg. 3325-32 (Jun 2015) ISSN: 1791-7530 [Electronic] Greece
• PMID: 26026092 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Chemical References

• Prodigiosin

Topics

• DNA Damage (drug effects)
• Genome, Human (drug effects)
• Humans
• MCF-7 Cells
• Neoplasms (drug therapy, pathology)
• Prodigiosin (administration & dosage, adverse effects)
• Serratia (chemistry, pathogenicity)
• Serratia Infections (complications, drug therapy, genetics)