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The Effect of Proton Pump Inhibitors on Barrett's Esophagus.

Abstract
Proton pump inhibitors (PPIs) may protect against carcinogenesis in Barrett's esophagus because they eliminate the chronic esophageal inflammation of reflux esophagitis, and because they decrease esophageal exposure to acid, which can cause cancer-promoting DNA damage and increase proliferation in Barrett's metaplasia. Most clinical studies of PPIs and cancer development in Barrett's esophagus have found a cancer-protective effect for these drugs, although there are some contradictory data. Chemoprevention of dysplasia and cancer in Barrett's esophagus with PPIs appears to be cost-effective, and the indirect evidence supporting a cancer-protective role for PPIs is strong enough to warrant PPI treatment of virtually all patients with Barrett's esophagus.
AuthorsKerry B Dunbar, Rhonda F Souza, Stuart J Spechler
JournalGastroenterology clinics of North America (Gastroenterol Clin North Am) Vol. 44 Issue 2 Pg. 415-24 (Jun 2015) ISSN: 1558-1942 [Electronic] United States
PMID26021202 (Publication Type: Journal Article, Review)
CopyrightPublished by Elsevier Inc.
Chemical References
  • Proton Pump Inhibitors
Topics
  • Adenocarcinoma (prevention & control)
  • Barrett Esophagus (drug therapy, pathology, surgery)
  • Carcinogenesis (drug effects)
  • Esophageal Neoplasms (prevention & control)
  • Gastroesophageal Reflux (drug therapy)
  • Humans
  • Precancerous Conditions (drug therapy, pathology)
  • Proton Pump Inhibitors (adverse effects, therapeutic use)

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