Abstract | BACKGROUND: METHODS: This double-blind randomized clinical trial was conducted on neonates with jaundice, who had received phototherapy in the hospitals affiliated with the Shiraz University of Medical Sciences in 2013. A total of 80 neonates were enrolled in the study and were randomly divided into 2 groups. The intervention group (n = 0) with indirect hyperbilirubinemia received 10 mg · kg(-1) · day(-1) divided every 12 hours Ursobil ( capsule 300 mg) in addition to phototherapy, whereas the control group (n = 0) received only phototherapy. Total bilirubin levels were measured every 12 hours until reaching <10 mg/dL, and then phototherapy was disrupted. The duration of phototherapy was measured. The 2 groups were compared regarding total bilirubin levels at different time points and duration of phototherapy using the generalized estimating equation (GEE) test. RESULTS: The mean of total bilirubin in the intervention group was 12 ± 1.6, 10 ± 1.1, and 9.8 ± 0.2 mg/dL 12, 24, and 48 hours after the beginning of phototherapy, respectively. On the contrary, these measures were 14.4 ± 1.3, 12.5 ± 1.4, and 10.1 ± 1.1 mg/dL in the control group, respectively, (P < 0.05). The mean time required for phototherapy to decrease the bilirubin level to < 10 mg/dL was 15.5 ± 6 and 44.6 ± 13.3 hours in the case and the control group, respectively, (P = 0.001). CONCLUSIONS:
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Authors | Naser Honar, Elham Ghashghaei Saadi, Forough Saki, Narjes Pishva, Nader Shakibazad, Saeed Hosseini Teshnizi |
Journal | Journal of pediatric gastroenterology and nutrition
(J Pediatr Gastroenterol Nutr)
Vol. 62
Issue 1
Pg. 97-100
(Jan 2016)
ISSN: 1536-4801 [Electronic] United States |
PMID | 26020375
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholagogues and Choleretics
- Ursodeoxycholic Acid
- Bilirubin
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Topics |
- Bilirubin
(blood)
- Cholagogues and Choleretics
(administration & dosage)
- Combined Modality Therapy
- Double-Blind Method
- Female
- Humans
- Hyperbilirubinemia
(blood, complications, therapy)
- Infant, Newborn
- Jaundice
(etiology, therapy)
- Length of Stay
- Male
- Phototherapy
(methods)
- Time Factors
- Treatment Outcome
- Ursodeoxycholic Acid
(administration & dosage)
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