Abstract | BACKGROUND: METHODS: Three hundred children aged 0-6 years were enrolled in a cohort study of malaria incidence in Bandiagara, Mali, with continuous passive and monthly active follow-up from June 2009 to June 2010. RESULTS: Compared to hemoglobin AA children (n = 242), hemoglobin AC children (n = 39) had a longer time to first clinical malaria episode (hazard ratio [HR], 0.19; P = .001; 364 median malaria-free days vs 181 days), fewer episodes of clinical malaria, and a lower cumulative parasite burden. Similarly, hemoglobin AS children (n = 14) had a longer time to first clinical malaria episode than hemoglobin AA children (HR, 0.15; P = .015; 364 median malaria-free days vs 181 days), but experienced the most asymptomatic malaria infections of any group. CONCLUSIONS: Both hemoglobin C and S traits exerted a protective effect against clinical malaria episodes, but appeared to do so by mechanisms that differentially affect the response to infecting malaria parasites.
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Authors | Mark A Travassos, Drissa Coulibaly, Matthew B Laurens, Ahmadou Dembélé, Youssouf Tolo, Abdoulaye K Koné, Karim Traoré, Amadou Niangaly, Aldiouma Guindo, Yukun Wu, Andrea A Berry, Christopher G Jacob, Shannon Takala-Harrison, Matthew Adams, Biraj Shrestha, Amy Z Mu, Bourema Kouriba, Kirsten E Lyke, Dapa A Diallo, Ogobara K Doumbo, Christopher V Plowe, Mahamadou A Thera |
Journal | The Journal of infectious diseases
(J Infect Dis)
Vol. 212
Issue 11
Pg. 1778-86
(Dec 01 2015)
ISSN: 1537-6613 [Electronic] United States |
PMID | 26019283
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. |
Chemical References |
- Hemoglobin, Sickle
- Hemoglobin C
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Topics |
- Child
- Child, Preschool
- Cohort Studies
- Female
- Genetic Predisposition to Disease
(epidemiology, genetics)
- Hemoglobin C
(genetics)
- Hemoglobin, Sickle
(genetics)
- Humans
- Incidence
- Infant
- Infant, Newborn
- Malaria, Falciparum
(epidemiology, genetics)
- Male
- Mali
(epidemiology)
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