[Medical treatment of the uterine miomas in perimenopausal patients].

Abstract

BACKGROUND:

Leiomyomas are the most common benign tumors of the uterus, frequently associated with abnormal uterine bleeding. Medroxyprogesterone (MP) acetate it is a therapeutic alternative.

OBJECTIVE:

To determine the efficacy of the medroxyprogesterone for abnormal uterine bleeding associated with leiomyomatosis in perimenopause women.

METHODS:

An observational, prospective, longitudinal study. We selected 31 patients with uterine myomas and abnormal uterine bleeding. Two years monthly doses of 150 mg of MP were given. If the bleeding did not stop at six months of treatment or increased a hysterectomy was performed.

RESULTS:

Two (6.4%) patients abandoned the treatment after a first doses; 21 (67.7%) completed the treatment without uterine bleeding (efficacy observed of 72.4%; CI 95% 54.4 to 90.4%, intention to treat efficacy 67.7%, CI 95% 49.6 to 86.8%). Eight (25.8%) patients persisted with uterine bleeding before 6 months of treatment and a hysterectomy was performed. There was no severity secondary effect informed.

CONCLUSIONS:

Management with medroxyprogesterone may be an effective treatment to control the uterine bleeding associated with myomatosis. Their use could reduce the necessity of some hysterectomies.

• Authors: Abraham Jovanny Olvera-Maldonado, Alfonso Martínez-Uribe, Mario Enrique Rendón-Macías, Augusto Sangines-Martínez
• Journal: Ginecologia y obstetricia de Mexico (Ginecol Obstet Mex) Vol. 83 Issue 1 Pg. 41-7 (Jan 2015) ISSN: 0300-9041 [Print] Mexico
• Vernacular Title: Tratamiento de los miomas uterinos con medroxiprogesterona en pacientes perimenopáusicas.
• PMID: 26016315 (Publication Type: Clinical Trial, Phase II, English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents, Hormonal
• Medroxyprogesterone Acetate

Topics

• Antineoplastic Agents, Hormonal (therapeutic use)
• Female
• Humans
• Hysterectomy (methods)
• Leiomyoma (drug therapy, pathology)
• Longitudinal Studies
• Medroxyprogesterone Acetate (therapeutic use)
• Middle Aged
• Perimenopause
• Prospective Studies
• Treatment Outcome
• Uterine Neoplasms (drug therapy, pathology)