Abstract | BACKGROUND: MATERIALS AND METHODS: We have measured the plasma 5-HT levels in 20 autistic male children and 20 control male children by the enzyme-linked immunosorbent assay (ELISA) method. In addition, the SLC6A4 promoter region (5-HTTLPR) insertion/deletion (I/D) polymorphism was studied, using whole genomic DNA. RESULTS: Plasma serotonin was significantly low in autistic children compared to control (P = 0.001), although correlation to severity of autism was not significant. The frequency of short (S) allele in autism cases was 10% and in the control group it was absent. CONCLUSION: Our study demonstrated an increased prevalence of 5-HTTLPR S allele in autism subjects. Significantly decreased plasma serotonin was detected in autism subjects, with no significant relationship between 5-HTTLPR genotype and plasma 5-HT being evident.
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Authors | Nagwa A Meguid, Ola H Gebril, Rehab O Khalil |
Journal | Advanced biomedical research
(Adv Biomed Res)
Vol. 4
Pg. 94
( 2015)
ISSN: 2277-9175 [Print] India |
PMID | 26015920
(Publication Type: Journal Article)
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