Soluble CD40L Is a Useful Marker to Predict Future Strokes in Patients With Minor Stroke and Transient Ischemic Attack.

Abstract

BACKGROUND AND PURPOSE:

Elevated soluble CD40 ligand (sCD40L) was shown to be related to cardiovascular events, but the role of sCD40L in predicting recurrent stroke remains unclear.

METHODS:

Baseline sCD40L levels were measured in 3044 consecutive patients with acute minor stroke and transient ischemic attack, who had previously been enrolled in the Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events (CHANCE) trial. Cox proportional-hazards model was used to assess the association of sCD40L with recurrent stroke.

RESULTS:

Patients in the top tertile of sCD40L levels had increased risk of recurrent stroke comparing with those in the bottom tertile, after adjusted for conventional confounding factors (hazard ratio, 1.49; 95% confidence interval, 1.11-2.00; P=0.008). The patients with elevated levels of both sCD40L and high-sensitive C-reactive protein also had increased risk of recurrent stroke (hazard ratio, 1.81; 95% confidence interval, 1.23-2.68; P=0.003).

CONCLUSIONS:

Elevated sCD40L levels independently predict recurrent stroke in patients with minor stroke and transient ischemic attack.

CLINICAL TRIAL REGISTRATION:

URL: http://www.clinicaltrials.gov. Unique identifier: NCT00979589.

• Authors: Jiejie Li, Yilong Wang, Jinxi Lin, David Wang, Anxin Wang, Xingquan Zhao, Liping Liu, Chunxue Wang, Yongjun Wang, CHANCE Investigators
• Journal: Stroke (Stroke) Vol. 46 Issue 7 Pg. 1990-2 (Jul 2015) ISSN: 1524-4628 [Electronic] United States
• PMID: 26012640 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 American Heart Association, Inc.

Chemical References

• Biomarkers
• CD40 Ligand

Topics

• Adult
• Biomarkers (blood)
• CD40 Ligand (blood)
• Female
• Follow-Up Studies
• Forecasting
• Humans
• Ischemic Attack, Transient (blood, diagnosis, epidemiology)
• Male
• Predictive Value of Tests
• Recurrence
• Risk Factors
• Stroke (blood, diagnosis, epidemiology)