[Clinical study of the combination therapy with intranasal antihistamine and nasal corticosteroids in the treatment of nasal obstruction of persistent non-allergic rhinitis].

Abstract

OBJECTIVE:

To determine if greater efficacy could be achieved with the intranasal antihistamine azelastine and the intranasal corticosteroid fluticasone propionate used concurrently in the treatment of nasal obstruction of persistent non-allergic rhinitis.

METHOD:

A total of 162 persistent non-allergic rhinitis cases with moderate to severe nasal obstruction were randomized to treatment with the following: the combination therapy or nasal corticosteroids monotherapy. Efficacy was assessed by change from baseline in nasal obstruction score at week 2 and week 6 visits. The perceptions of global treatment satisfaction(convenience, side effects, cost and effectiveness) in both groups were analyzed.

RESULT:

In both groups, the nasal obstruction score assessment descended significantly at week 2 and week 6 visits versus at baseline (all P < 0.01). At week 2 and week 6 visits, the nasal obstruction score in the combination therapy groups were significantly improved than that in nasal corticosteroids monotherapy groups (all P < 0.01). The perceptions of global treatment satisfaction in the combination therapy groups were significantly better (P < 0.05).

CONCLUSION:

Azelastine nasal spray and intranasal corticosteroid in combination may provide a substantial therapeutic benefit for patients with persistent non-allergic rhinitis, especially nasal obstruction. The combination therapy was well tolerated and safety.

• Authors: Limin Guo, Xicai Sun, Juanmei Yang, Juan Liu, Dehui Wang
• Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery (Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 29 Issue 3 Pg. 243-5, 251 (Feb 2015) ISSN: 2096-7993 [Print] China
• PMID: 26012297 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Adrenal Cortex Hormones
• Histamine H1 Antagonists
• Phthalazines
• azelastine

Topics

• Administration, Intranasal
• Adrenal Cortex Hormones (therapeutic use)
• Drug Therapy, Combination
• Histamine H1 Antagonists (therapeutic use)
• Humans
• Nasal Obstruction
• Phthalazines (therapeutic use)
• Rhinitis (drug therapy)