Abstract | INTRODUCTION: OBJECTIVE: METHODS: A meta-analysis of controlled clinical trials in 12 databases based on the implementation of a research protocol with inclusion and exclusion criteria and an assessment of methodological quality. The reproducibility and completeness were guaranteed in the information search and extraction. Heterogeneity, sensitivity and publication bias were assessed by graphical methods (Galbraith, L'Abblé, funnel plot, Egger plot, and influence plot) and analytical methods (DerSimonian-Laird, Begg and Egger). Random-effects forest plots were constructed, and a cumulative meta-analysis was performed. RESULTS: Eight studies were included with 622 patients who underwent thermotherapy, with an efficacy of 73.2% (95% confidence interval (CI) = 69.6-76.7%), and with 667 patients who underwent systemic treatment, with an efficacy of 70.6% (95% CI=67.1-74.1%). Heterogeneity between studies, good sensitivity for the combined measure, and no publication bias were observed. The relative risk for comparison of the efficacy of treatment was 1.02 (95%CI=0.91, 1.15), showing that the effectiveness of thermotherapy is equal to that of pentavalent antimonial drugs. CONCLUSION:
|
Authors | Jaiberth Antonio Cardona-Arias, Iván Darío Vélez, Liliana López-Carvajal |
Journal | PloS one
(PLoS One)
Vol. 10
Issue 5
Pg. e0122569
( 2015)
ISSN: 1932-6203 [Electronic] United States |
PMID | 26009885
(Publication Type: Journal Article, Meta-Analysis)
|
Chemical References |
- Organometallic Compounds
- Meglumine
- Meglumine Antimoniate
|
Topics |
- Confidence Intervals
- Controlled Clinical Trials as Topic
- Humans
- Hyperthermia, Induced
- Leishmaniasis, Cutaneous
(drug therapy, therapy)
- Meglumine
(therapeutic use)
- Meglumine Antimoniate
- Models, Biological
- Organometallic Compounds
(therapeutic use)
- Treatment Outcome
|