Multifunctional Gadolinium-Doped Manganese Carbonate Nanoparticles for Targeted MR/Fluorescence Imaging of Tiny Brain Gliomas.

Abstract

Manganese (Mn)-based nanoparticles have been proved to be promising MR T1 contrast agents for the diagnosis of brain tumors. However, most of them exhibit a low relaxation rate, resulting in an insufficient enhancement effect on tiny gliomas. Herein, we developed gadolinium (Gd)-doped MnCO3 nanoparticles with a size of 11 nm via the thermal decomposition of Mn-oleate in the presence of Gd-oleate. Owing to the small size and Gd doping, these Gd-doped MnCO3 NPs, when endowed with excellent aqueous dispersibility and colloidal stability, exhibited a high r1 relaxivity of 6.81 mM(-1) s(-1). Moreover, the Gd/MnCO3 NPs were used as a reliable platform to construct a glioma-targeted MR/fluorescence bimodal nanoprobe. The high relaxivity, the bimodal imaging capability, and the specificity nominate the multifunctional Gd doped MnCO3 NPs as an effective nanoprobe for the diagnostic imaging of tiny brain gliomas with an improved efficacy.

• Authors: Chen Shao, Shuai Li, Wei Gu, Ningqiang Gong, Juan Zhang, Ning Chen, Xiangyang Shi, Ling Ye
• Journal: Analytical chemistry (Anal Chem) Vol. 87 Issue 12 Pg. 6251-7 (Jun 16 2015) ISSN: 1520-6882 [Electronic] United States
• PMID: 26008220 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carbonates
• Contrast Media
• Manganese
• manganese carbonate
• Gadolinium

Topics

• Animals
• Brain (diagnostic imaging, pathology)
• Carbonates (chemistry)
• Contrast Media (chemical synthesis, chemistry)
• Fluorescence
• Gadolinium (chemistry)
• Glioma (diagnosis, diagnostic imaging)
• Humans
• Magnetic Resonance Imaging
• Manganese (chemistry)
• Mice
• Mice, Nude
• Microscopy, Confocal
• NIH 3T3 Cells
• Nanoparticles (chemistry)
• Neoplasms, Experimental (diagnosis, diagnostic imaging)
• Radiography
• Tumor Cells, Cultured