Serum sclerostin is decreased following vitamin D treatment in young vitamin D-deficient female adults.

Abstract

Sclerostin is produced almost exclusively by osteocytes, which also express receptors for 1,25 dihydroxyvitamin D3. The aim of this study was to investigate the effects of vitamin D3 treatment on serum sclerostin levels in young adult females with severe vitamin D deficiency. A total of 26 subjects were treated orally with calcium (1.200 mg/day for 2 months) and vitamin D3 (300.000 IU/week for 1 month). Serum 25-hydroxyvitamin D (25(OH)D) and sclerostin levels were measured before and after treatment. Baseline serum 25(OH)D and sclerostin levels were at 5.7 ± 2.4 ng/mL and 39.1 ± 14.4 pg/mL, respectively. Serum 25(OH)D was significantly increased, to 62.4 ± 18.7 ng/mL, following treatment; serum sclerostin was significantly decreased, to 29.3 ± 8.8 pg/mL. We conclude that serum sclerostin level is decreased following vitamin D3 treatment in patients with vitamin D deficiency.

• Authors: Muharrem Cidem, Ilhan Karacan, Neval Bozok Arat, Oguzhan Zengi, Murat Ozkaya, Saadet Pilten Guzel, Cansu Ozkan, Ozan Beytemur
• Journal: Rheumatology international (Rheumatol Int) Vol. 35 Issue 10 Pg. 1739-42 (Oct 2015) ISSN: 1437-160X [Electronic] Germany
• PMID: 26007153 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adaptor Proteins, Signal Transducing
• Bone Morphogenetic Proteins
• Genetic Markers
• SOST protein, human
• Cholecalciferol
• Calcium

Topics

• Adaptor Proteins, Signal Transducing
• Adult
• Bone Morphogenetic Proteins (blood)
• Calcium (therapeutic use)
• Cholecalciferol (therapeutic use)
• Female
• Genetic Markers
• Humans
• Vitamin D Deficiency (blood, drug therapy)