Increased dose of betamethasone for transforaminal epidural steroid injections is not associated with superior pain outcomes at 4 weeks.

Abstract

BACKGROUND:

Fluoroscopically guided transforaminal epidural steroid injections (FG-TFESIs) have been shown to provide both immediate and long-term improvement in patient's self-reported pain. Administration of the lowest possible dose of epidural betamethasone is desired to minimize side effects while maintaining efficacy. We hypothesize that a 3 mg or a 6 mg dose of betamethasone will demonstrate equivalent analgesic properties.

OBJECTIVES:

To compare the analgesic efficacy of 3 mg and a 6 mg dose of betamethasone for use in FG-TFESI.

STUDY DESIGN:

Retrospective evaluation.

SETTING:

Academic outpatient pain center.

METHODS:

One hundred fifty-eight patients underwent FG-TFESI for lumbar back pain between 2012 and 2013. Depending on the date of service, a dose of 3 mg or a dose of 6 mg betamethasone was used in the single level unilateral TFESI. Opioid consumption and NRS pain score were analyzed pre-procedurally and at a clinic visit 4 weeks post-procedurally.

RESULTS:

Changes in numerical rating scale (NRS) pain score (-1.21 +' 2.61 vs. -0.81 +' 2.40 respectively, P = 0.17) and changes in opioid consumption as measured in oral morphine equivalents (-2.94 +' 16.4 mg vs. -2.93 +' 14.8 mg, P = 0.17) were statistically equivalent between both groups. Intergroup sub-analysis of those with > 50% reduction in baseline VRS {sp} pain score was not different (15.2% vs. 34%, P = 0.56), and the proportion with a VRS pain score < 3 were similar (24.5% vs. 23.8%, P = 0.92).

LIMITATIONS:

Potential selection bias inherent with study design.

CONCLUSIONS:

Reduction in NRS pain scores and narcotic usage at 4 weeks after FG-TFESI were statistically equivalent between patients who received 3 mg or 6 mg of betamethasone, suggesting that a lower steroid dose has similar analgesic efficacy. IRB Number: Cedars Sinai Medical Center Institutional Review Board Pro00031594

• Authors: Waylan Wong, Dermot P Maher, Daniel Iyayi, Raul Lopez, Bahman Shamloo, Howard Rosner, Roya Yumul
• Journal: Pain physician (Pain Physician) 2015 May-Jun Vol. 18 Issue 3 Pg. E355-61 ISSN: 2150-1149 [Electronic] United States
• PMID: 26000682 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Steroids
• Betamethasone

Topics

• Adult
• Aged
• Anti-Inflammatory Agents (administration & dosage)
• Betamethasone (administration & dosage)
• Dose-Response Relationship, Drug
• Female
• Humans
• Injections, Epidural
• Low Back Pain (diagnosis, drug therapy)
• Male
• Middle Aged
• Pain Measurement (drug effects, methods, trends)
• Retrospective Studies
• Steroids (administration & dosage)
• Time Factors
• Treatment Outcome