Acute Generalized Exanthematous Pustulosis Induced by Amoxicillin/Clavulanic Acid: Report of a Case Presenting With Generalized Lymphadenopathy.

Abstract

Drug-induced acute generalized exanthematous pustulosis is a rare pustular skin reaction, most commonly triggered by antibiotics. Although its diagnosis is based primarily on the presence of specific clinical and histopathologic features, additional in vivo (patch testing) or in vitro testing may be required, especially in atypical cases, to more accurately determine the causative agent. The authors report a histologically confirmed case of acute generalized exanthematous pustulosis that was induced by amoxicillin/clavulanic acid, as documented by subsequent patch testing, and presented with generalized painful lymphadenopathy, mimicking an acute infectious process. This is a very rare and diagnostically challenging clinical presentation of acute generalized exanthematous pustulosis, which has been reported, to the best of our knowledge, only once previously.

• Authors: Ekaterini Syrigou, Dimitra Grapsa, Andriani Charpidou, Konstantinos Syrigos
• Journal: Journal of cutaneous medicine and surgery (J Cutan Med Surg) 2015 Nov-Dec Vol. 19 Issue 6 Pg. 592-4 ISSN: 1203-4754 [Print] United States
• PMID: 25997755 (Publication Type: Case Reports, Journal Article)
• Copyright: © The Author(s) 2015.

Chemical References

• beta-Lactamase Inhibitors
• Amoxicillin-Potassium Clavulanate Combination

Topics

• Acute Generalized Exanthematous Pustulosis (diagnosis, etiology)
• Adult
• Amoxicillin-Potassium Clavulanate Combination (adverse effects)
• Female
• Humans
• Lymphatic Diseases (chemically induced, diagnosis)
• Patch Tests
• beta-Lactamase Inhibitors (adverse effects)