Abstract | PURPOSE: METHODS: Twenty-nine Asian Indian infants with aggressive posterior retinopathy of prematurity were randomized; each eye received 1 of 2 methods (29 each in Group A or B) proposed by the PHOTO-ROP group. Group A underwent single session laser to the avascular retina underlying the flat neovascularization by direct laser over the fronds. Group B underwent laser in 2 sessions; first, laser was delivered to the avascular periphery up to the flat neovascularization and 7 days later to the avascular bed exposed by the retraction of the fronds. Outcome and complications between the two groups were compared. RESULTS: Mean birthweight and gestational ages were 1,276 g and 30.1 weeks, respectively. All eyes showed favorable outcome at a minimum 12-month follow-up. Hemorrhages after laser (41.4% vs. 17.2%, P < 0.001) were more common in the single laser group. Large hemorrhages (>1 disk diameter) seen in Group A took longer than 8 weeks to resolve and developed focal fibrosis. CONCLUSION: This study demonstrates that the two-staged laser procedure produces fewer and smaller hemorrhages and no fibrosis compared with a single session. Both methods have comparable favorable outcomes in Asian Indian infants.
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Authors | Anand Vinekar, Chaitra Jayadev, Shwetha Mangalesh, Anupama Kiran Kumar, Noel Bauer, Antonio Capone Jr, Michael Trese, Bhujang Shetty |
Journal | Retina (Philadelphia, Pa.)
(Retina)
Vol. 35
Issue 10
Pg. 2130-6
(Oct 2015)
ISSN: 1539-2864 [Electronic] United States |
PMID | 25996425
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Topics |
- Birth Weight
- Fibrosis
- Follow-Up Studies
- Gestational Age
- Humans
- Laser Coagulation
(adverse effects, methods)
- Postoperative Complications
- Prospective Studies
- Retina
(pathology)
- Retinal Hemorrhage
(etiology, prevention & control)
- Retinal Neovascularization
(physiopathology, surgery)
- Retinopathy of Prematurity
(physiopathology, surgery)
- Treatment Outcome
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