Toward organometallic antischistosomal drug candidates.

Abstract

In the recent years, there has been a growing interest in the use of novel approaches for the treatment of parasitic diseases such as schistosomiasis. Among the different approaches used, organometallic compounds were found to offer unique opportunities in the design of antiparasitic drug candidates. A ferrocenyl derivative, namely ferroquine, has even entered clinical trials as a novel antimalarial. In this short review, we report on the studies describing the use of organometallic compounds against schistosomiasis.

• Authors: Jeannine Hess, Jennifer Keiser, Gilles Gasser
• Journal: Future medicinal chemistry (Future Med Chem) Vol. 7 Issue 6 Pg. 821-30 ( 2015) ISSN: 1756-8927 [Electronic] England
• PMID: 25996072 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Antifungal Agents
• Antimalarials
• Organometallic Compounds
• Schistosomicides
• Praziquantel

Topics

• Animals
• Antifungal Agents (chemistry, pharmacology)
• Antimalarials (chemistry, pharmacology)
• Drug Discovery
• Drug Repositioning
• Humans
• Organometallic Compounds (chemistry, pharmacology)
• Praziquantel (analogs & derivatives, pharmacology)
• Schistosoma (drug effects)
• Schistosomiasis (drug therapy, parasitology)
• Schistosomicides (chemistry, pharmacology)