Abstract | INTRODUCTION:
Acute lung injury (ALI) is an acute inflammatory disease characterized by excess production of inflammatory factors in lung tissue. Quercetin, a herbal flavonoid, exhibits anti-inflammatory and anti-oxidative properties. This study was performed to assess the effects of quercetin on lipopolysaccharide (LPS)-induced ALI. MATERIAL AND METHODS: Sprague-Dawley rats were randomly divided into 3 groups: the control group (saline alone), the LPS group challenged with LPS (Escherichia coli 026:B6; 100 µg/kg), and the quercetin group pretreated with quercetin (50 mg/kg, by gavage) 1 h before LPS challenge. Bronchoalveolar lavage fluid (BALF) samples and lung tissues were collected 6 h after LPS administration. Histopathological and biochemical parameters were measured. RESULTS: CONCLUSIONS:
Quercetin pretreatment effectively ameliorates LPS-induced ALI, largely through suppression of inflammation and oxidative stress, and may thus have therapeutic potential in the prevention of this disease.
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Authors | Risheng Huang, Tian Zhong, Hao Wu |
Journal | Archives of medical science : AMS
(Arch Med Sci)
Vol. 11
Issue 2
Pg. 427-32
(Apr 25 2015)
ISSN: 1734-1922 [Print] Poland |
PMID | 25995762
(Publication Type: Journal Article)
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