Abstract |
To evaluate the efficacy and safety of compound Decumbent Corydalis Rhizome (DCR) in treating patients with knee osteoarthritis (OA). Totally 79 patients with knee osteoarthritis were selected from out-patient and inpatient departments of West China Hospital and randomly divided into the test group and the control group. The test group (n = 41) was given Compound DCR with the dosage of 1.8 g · d(-1), while the control group (n = 38) was administered with diclofenac sodium with the dosage of 75 mg · d(-1). After 12 weeks of treatment, the total efficacy rates based on patients/physicians evaluation for experimental and control groups were 68.29%, 63.41% and 71.05%, 63.16%, respectively, without significant difference between the two groups. Both of the two groups showed significant improvements in the main efficacy indexes ( pain on walking 20 m) and minor indexes (tenderness on palpation, Western Ontario and McMaster Universities OA index (WOMAC) and Short-Form Health Survey (SF-36 ), but without significant difference in efficacy between them. The incidence of related adverse events was 24.39% in the test group and 47.37% in the control group, respectively, with significant differences between the two groups (P < 0.05). In the controlled study, compound DCR is as efficient as diclofenac sodium but more tolerable, with a good clinical application prospect.
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Authors | Chuan Zuo, Geng Yin, Xiao-Min Cen, Qi-Bing Xie |
Journal | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
(Zhongguo Zhong Yao Za Zhi)
Vol. 40
Issue 1
Pg. 149-53
(Jan 2015)
ISSN: 1001-5302 [Print] China |
PMID | 25993805
(Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Drugs, Chinese Herbal
- Diclofenac
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Topics |
- Adult
- Aged
- Corydalis
(chemistry)
- Diclofenac
(administration & dosage)
- Drugs, Chinese Herbal
(administration & dosage)
- Female
- Humans
- Male
- Middle Aged
- Osteoarthritis, Knee
(drug therapy)
- Rhizome
(chemistry)
- Treatment Outcome
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