Assessment of human sinus cavity air volume using tunable diode laser spectroscopy, with application to sinusitis diagnostics.

Abstract

Sinusitis is a very common disease and improved diagnostic tools are desirable also in view of reducing over-prescription of antibiotics. A non-intrusive optical technique called GASMAS (GAs in Scattering Media Absorption Spectroscopy), which has a true potential of being developed into an important complement to other means of detection, was utilized in this work. Water vapor in the frontal sinuses, related to the free gas volume, was studied at around 937 nm in healthy volunteers. The results show a good stability of the GASMAS signals over extended times for the frontal sinuses for all volunteers, showing promising applicability to detect anomalies due to sinusitis. Measurements were also performed following the application of a decongestion spray. No noticeable signal change was observed, which is consistent with the fact that the water vapor concentration is given by the temperature only, and is not influenced by changes in cavity ventilation. Evaluated GASMAS data recorded on 6 consecutive days show signal stability for the left and right frontal sinus in one of the test volunteers.

• Authors: Jing Huang, Hao Zhang, Tianqi Li, Huiying Lin, Katarina Svanberg, Sune Svanberg
• Journal: Journal of biophotonics (J Biophotonics) Vol. 8 Issue 11-12 Pg. 985-92 (Nov 2015) ISSN: 1864-0648 [Electronic] Germany
• PMID: 25990508 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Nasal Decongestants
• Steam

Topics

• Equipment Design
• Female
• Frontal Sinus (anatomy & histology, chemistry, pathology)
• Humans
• Lasers
• Male
• Nasal Decongestants (administration & dosage)
• Optical Imaging (instrumentation, methods)
• Organ Size
• Reproducibility of Results
• Sinusitis (diagnosis, metabolism, pathology)
• Spectrum Analysis (instrumentation, methods)
• Steam
• Temperature