Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.

Abstract

To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.

• Authors: J W M van der Linden, M C Arendrup, A Warris, K Lagrou, H Pelloux, P M Hauser, E Chryssanthou, E Mellado, S E Kidd, A M Tortorano, E Dannaoui, P Gaustad, J W Baddley, A Uekötter, C Lass-Flörl, N Klimko, C B Moore, D W Denning, A C Pasqualotto, C Kibbler, S Arikan-Akdagli, D Andes, J Meletiadis, L Naumiuk, M Nucci, W J G Melchers, P E Verweij
• Journal: Emerging infectious diseases (Emerg Infect Dis) Vol. 21 Issue 6 Pg. 1041-4 (Jun 2015) ISSN: 1080-6059 [Electronic] United States
• PMID: 25988348 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Antifungal Agents
• Azoles

Topics

• Antifungal Agents (pharmacology)
• Aspergillosis (epidemiology, microbiology)
• Aspergillus fumigatus (drug effects, genetics)
• Azoles (pharmacology)
• Drug Resistance, Fungal
• Humans
• Microbial Sensitivity Tests
• Mutation
• Population Surveillance
• Prevalence
• Prospective Studies