Female third party lymphocytes are effective for immunotherapy of patients with unexplained primary recurrent spontaneous abortion: A retrospective analysis of outcomes.

Abstract

OBJECTIVES:

Allogeneic lymphocytes of paternal origin or supplied by a male third party have been used for the treatment of recurrent spontaneous abortion. Few studies, however, have examined the use of female third party lymphocytes. Our purpose was to determine whether female third party lymphocytes could be used for immunotherapy of women with recurrent spontaneous abortion.

METHODS:

In this retrospective non-randomised cohort-controlled study, the medical records of patients with three or more spontaneous abortions who received immunotherapy with lymphocytes from their partner, a male third party or a female third party, as well as those who received no immunotherapy, from 1996 to 2012 were reviewed. All patients were negative for mixed lymphocyte culture reaction (MLR)-blocking antibodies. Immunotherapy was performed in 302 patients in two courses, while 53 patients received no immunotherapy.

RESULTS:

The pregnancy rates in patients who received lymphocytes from their partners, a male third party or a female third party, and in those not immunised, were 85.6%, 87.3%, 89.7%, and 79.3%, respectively (p = 0.523);the live birth rates were 87.3%, 75.8%, 84.6%, and 40.5%, respectively (p < 0.001).

CONCLUSIONS:

We conclude that female third party lymphocytes can be used for immunotherapy in patients with recurrent spontaneous abortion.

• Authors: Xu Liang, Tian Qiu, Lihua Qiu, Xipeng Wang, Aimin Zhao, Qide Lin
• Journal: The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception (Eur J Contracept Reprod Health Care) Vol. 20 Issue 6 Pg. 428-37 ( 2015) ISSN: 1473-0782 [Electronic] England
• PMID: 25985825 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Blocking

Topics

• Abortion, Habitual (therapy)
• Adult
• Antibodies, Blocking (analysis)
• Female
• Humans
• Immunotherapy (methods)
• Live Birth
• Lymphocyte Culture Test, Mixed
• Lymphocyte Transfusion
• Male
• Pregnancy
• Pregnancy Rate
• Retrospective Studies
• Time Factors
• Transplantation, Homologous
• Young Adult