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Aggressive Central Giant Cell Granuloma of the Mandible Treated With Conservative Surgical Enucleation and Interferon-α-2a: Complete Remission With Long-Term Follow-Up.

Abstract
Central giant cell granuloma (CGCG) is a benign tumor of the jaws. Aggressive lesions present a strong tendency toward recurrence after surgical enucleation; thus, en bloc resection and microvascular bone free flap transfer are usually performed. However, in young patients, aggressive surgical treatment is a not always suitable solution. This report describes the case of a young female patient who developed an aggressive recurrence of CGCG after its diagnosis and enucleation from the mandible. Surgical enucleation with subcutaneous injection of interferon-α-2a was performed. The patient was evaluated every 6 weeks, and after 6 months radiographic evidence of complete bone regeneration was obtained. No sign of recurrence was seen after 8 years of follow-up. A review of the literature proved that interferon treatment is an effective strategy to avoid extensive surgery in patients with aggressive CGCG.
AuthorsAchille Tarsitano, Giacomo Del Corso, Angelo Pizzigallo, Claudio Marchetti
JournalJournal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons (J Oral Maxillofac Surg) Vol. 73 Issue 11 Pg. 2149-54 (Nov 2015) ISSN: 1531-5053 [Electronic] United States
PMID25985764 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.
Chemical References
  • Interferon alpha-2
  • Interferon-alpha
  • Recombinant Proteins
Topics
  • Adult
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Granuloma, Giant Cell (diagnostic imaging, drug therapy, surgery)
  • Humans
  • Interferon alpha-2
  • Interferon-alpha (therapeutic use)
  • Mandibular Neoplasms (diagnostic imaging, drug therapy, surgery)
  • Radiography, Panoramic
  • Recombinant Proteins (therapeutic use)
  • Remission Induction

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