Abstract |
Central giant cell granuloma (CGCG) is a benign tumor of the jaws. Aggressive lesions present a strong tendency toward recurrence after surgical enucleation; thus, en bloc resection and microvascular bone free flap transfer are usually performed. However, in young patients, aggressive surgical treatment is a not always suitable solution. This report describes the case of a young female patient who developed an aggressive recurrence of CGCG after its diagnosis and enucleation from the mandible. Surgical enucleation with subcutaneous injection of interferon-α-2a was performed. The patient was evaluated every 6 weeks, and after 6 months radiographic evidence of complete bone regeneration was obtained. No sign of recurrence was seen after 8 years of follow-up. A review of the literature proved that interferon treatment is an effective strategy to avoid extensive surgery in patients with aggressive CGCG.
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Authors | Achille Tarsitano, Giacomo Del Corso, Angelo Pizzigallo, Claudio Marchetti |
Journal | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
(J Oral Maxillofac Surg)
Vol. 73
Issue 11
Pg. 2149-54
(Nov 2015)
ISSN: 1531-5053 [Electronic] United States |
PMID | 25985764
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2015 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Interferon alpha-2
- Interferon-alpha
- Recombinant Proteins
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Topics |
- Adult
- Combined Modality Therapy
- Female
- Follow-Up Studies
- Granuloma, Giant Cell
(diagnostic imaging, drug therapy, surgery)
- Humans
- Interferon alpha-2
- Interferon-alpha
(therapeutic use)
- Mandibular Neoplasms
(diagnostic imaging, drug therapy, surgery)
- Radiography, Panoramic
- Recombinant Proteins
(therapeutic use)
- Remission Induction
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