Abstract |
A 65-year-old female with biopsy-confirmed nephrogenic systemic fibrosis (NSF) received a kidney transplantation. Despite good kidney function, her symptoms continued to progress. Deferoxamine was administered intramuscularly at 500 mg/day and later 1000 mg/day after 1 week with no adverse effects. Urine excretion of gadolinium increased from 6.0 μg/day to 11.6 μg/day and subsequently to 13.0 μg/day with 500 mg/day and 1000 mg/day of deferoxamine, respectively. Serum levels, however, remain unchanged from 1.7 ng/ml to 1.4 ng/ml. Although chelation therapy may have a role in the treatment of NSF, deferoxamine is too weak and a stronger chelator is needed.
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Authors | Nelson Leung, Mark R Pittelkow, Christine U Lee, Jonathan A Good, Matthew M Hanley, Thomas P Moyer |
Journal | NDT plus
(NDT Plus)
Vol. 2
Issue 4
Pg. 309-11
(Aug 2009)
ISSN: 1753-0784 [Print] England |
PMID | 25984024
(Publication Type: Case Reports)
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