Abstract | INTRODUCTION: AREAS COVERED: This review focuses on new tyrosine kinase inhibitors (TKIs) under investigation in these patients. Study design, phase of investigation, result and emerging toxicities were reported for each molecule. Combination trials involving TKIs with other strategies such as immunotherapy were also covered. EXPERT OPINION: Despite the development of more potent and more specific VEGFR TKIs, all tumors ultimately develop resistance to therapy and a plateau has been reached in terms of overall survival. Current research effort to develop new agents aims at overcoming both the primary and the acquired resistance to anti-VEGFR TKIs focusing on new molecular pathways. The ultimate goal is not only to improve patient outcome but to achieve durable complete remission. Several pitfalls that have been responsible for failure of other compounds remain, especially the lack of strong predictive biomarkers and the use of inappropriate tumor assessment criteria that may not accurately capture response to these new therapies.
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Authors | Roberto Iacovelli, Laurence Albiges, Bernard Escudier |
Journal | Expert opinion on emerging drugs
(Expert Opin Emerg Drugs)
Vol. 20
Issue 3
Pg. 379-92
(Sep 2015)
ISSN: 1744-7623 [Electronic] England |
PMID | 25982181
(Publication Type: Journal Article, Review)
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Chemical References |
- Antineoplastic Agents
- Biological Factors
- Protein Kinase Inhibitors
- Receptors, Vascular Endothelial Growth Factor
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Topics |
- Animals
- Antineoplastic Agents
(pharmacology)
- Biological Factors
(pharmacology)
- Carcinoma, Renal Cell
(drug therapy, pathology)
- Drug Design
- Drug Resistance, Neoplasm
- Humans
- Kidney Neoplasms
(drug therapy, pathology)
- Prognosis
- Protein Kinase Inhibitors
(pharmacology)
- Receptors, Vascular Endothelial Growth Factor
(antagonists & inhibitors)
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