Radio-opaque liposomes for the improved visualisation of focal liver disease by computerized tomography.

Abstract	Liposomes laden with radio-opaque agents (ROA) were prepared by the reverse phase evaporation method. The liposome solutions--containing 1.7-2.5 mg iodine per mg lipid--were injected into Wistar rats. 60 min post injection the rats were scanned in a Siemens CT scanner. Following the injection of 260 mg encapsulated iodine per kg bodyweight--less than half the iodine of the normal ROA bolus injection--there was a long lasting arise in liver enhancement of 40 Hounsfield units (HU). In animals with liver tumours induced by nitrosamine lesions of 2-3 mm in diameter could be detected.
Authors	A Henze, J Freise, P Magerstedt, A Majewski
Journal	Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society (Comput Med Imaging Graph) 1989 Nov-Dec Vol. 13 Issue 6 Pg. 455-62 ISSN: 0895-6111 [Print] United States
PMID	2598154 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Contrast Media Liposomes Triiodobenzoic Acids Iothalamic Acid iotrolan Diethylnitrosamine Iohexol iopromide meglumine ioglicinate Ioxaglic Acid
Topics	Animals Contrast Media Diethylnitrosamine Female Iohexol Iothalamic Acid Ioxaglic Acid Liposomes Liver (diagnostic imaging) Liver Neoplasms, Experimental (diagnostic imaging) Rats Rats, Inbred Strains Tomography, X-Ray Computed Triiodobenzoic Acids

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