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Curcumin-encapsulated polymeric micelles suppress the development of colon cancer in vitro and in vivo.

Abstract
To develop injectable formulation and improve the stability of curcumin (Cur), Cur was encapsulated into monomethyl poly (ethylene glycol)-poly (ε-caprolactone)-poly (trimethylene carbonate) (MPEG-P(CL-co-TMC)) micelles through a single-step solid dispersion method. The obtained Cur micelles had a small particle size of 27.6 ± 0.7 nm with polydisperse index (PDI) of 0.11 ± 0.05, drug loading of 14.07 ± 0.94%, and encapsulation efficiency of 96.08 ± 3.23%. Both free Cur and Cur micelles efficiently suppressed growth of CT26 colon carcinoma cells in vitro. The results of in vitro anticancer studies confirmed that apoptosis induction and cellular uptake on CT26 cells had completely increased in Cur micelles compared with free Cur. Besides, Cur micelles were more effective in suppressing the tumor growth of subcutaneous CT26 colon in vivo, and the mechanisms included the inhibition of tumor proliferation and angiogenesis and increased apoptosis of tumor cells. Furthermore, few side effects were found in Cur micelles. Overall, our findings suggested that Cur micelles could be a stabilized aqueous formulation for intravenous application with improved antitumor activity, which may be a potential treatment strategy for colon cancer in the future.
AuthorsXi Yang, Zhaojun Li, Ning Wang, Ling Li, Linjiang Song, Tao He, Lu Sun, Zhihan Wang, Qinjie Wu, Na Luo, Cheng Yi, Changyang Gong
JournalScientific reports (Sci Rep) Vol. 5 Pg. 10322 (May 18 2015) ISSN: 2045-2322 [Electronic] England
PMID25980982 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Angiogenesis Inhibitors
  • Antineoplastic Agents, Phytogenic
  • Micelles
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Polymers
  • Curcumin
Topics
  • Angiogenesis Inhibitors (administration & dosage)
  • Animals
  • Antineoplastic Agents, Phytogenic (administration & dosage)
  • Apoptosis (drug effects)
  • Cell Line, Tumor
  • Cell Proliferation (drug effects)
  • Cell Survival
  • Cell Transformation, Neoplastic (drug effects)
  • Colonic Neoplasms (metabolism, pathology)
  • Curcumin (administration & dosage)
  • Disease Models, Animal
  • Drug Liberation
  • Female
  • Humans
  • Inhibitory Concentration 50
  • Micelles
  • Particle Size
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Polymers (chemistry)
  • Xenograft Model Antitumor Assays

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