Abstract | BACKGROUND: Glycated albumin is a useful glycaemic control indicator for neonatal diabetes mellitus. However, glycated albumin concentrations in infants are lower than those in adults and increase in an age-dependent manner. Based on our investigation of non-diabetic subjects, we proposed the possibility that the reference range for adults may be used regardless of age, provided that age-adjusted glycated albumin is employed. In the present study, we evaluate the usefulness of age-adjusted glycated albumin in neonatal diabetes mellitus patients. METHODS: RESULTS: Measured glycated albumin was significantly lower than calculated glycated albumin (20.5 ± 4.9% versus 28.2 ± 6.1%; p < 0.0001), whereas age-adjusted glycated albumin was equivalent to calculated glycated albumin, showing no significant difference (27.5 ± 6.8% versus 28.2 ± 6.1%). Measured glycated albumin concentrations in patients with transient neonatal diabetes mellitus in remission were lower than the reference range for adults, whereas age-adjusted glycated albumin concentrations were within the reference range for adults. CONCLUSION: We demonstrated that age-adjusted glycated albumin concentrations were consistent with calculated glycated albumin. Age-adjusted glycated albumin is therefore a useful glycaemic control indicator for neonatal diabetes mellitus patients.
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Authors | Shigeru Suzuki, Akiko Furuya, Miho Oshima, Satoshi Amamiya, Atsushi Nakao, Keiko Wada, Koji Okuhara, Satoshi Hayano, Aya Imamoto, Kumihiro Matsuo, Yusuke Tanahashi, Hiroshi Azuma, Masafumi Koga |
Journal | Annals of clinical biochemistry
(Ann Clin Biochem)
Vol. 53
Issue Pt 1
Pg. 117-23
(Jan 2016)
ISSN: 1758-1001 [Electronic] England |
PMID | 25977574
(Publication Type: Comparative Study, Journal Article)
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Copyright | © The Author(s) 2015. |
Chemical References |
- Blood Glucose
- Glycation End Products, Advanced
- Serum Albumin
- Glycated Serum Albumin
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Topics |
- Adult
- Aging
(blood)
- Blood Chemical Analysis
(methods)
- Blood Glucose
(analysis)
- Diabetes Mellitus
(blood)
- Female
- Glycation End Products, Advanced
- Humans
- Infant
- Infant, Newborn
- Male
- Serum Albumin
(analysis)
- Glycated Serum Albumin
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