Abstract | BACKGROUND: METHODS AND RESULTS: CONCLUSIONS: The data demonstrate that H2S bioavailability and nuclear factor-erythroid 2-related factor 2 activation are both attenuated in CLI tissues concomitant with significantly increased oxidative stress. Reductions in the activity of H2S-producing enzymes may contribute to the pathogenesis of CLI.
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Authors | Kazi N Islam, David J Polhemus, Erminia Donnarumma, Luke P Brewster, David J Lefer |
Journal | Journal of the American Heart Association
(J Am Heart Assoc)
Vol. 4
Issue 5
(May 14 2015)
ISSN: 2047-9980 [Electronic] England |
PMID | 25977470
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. |
Chemical References |
- Biomarkers
- NF-E2-Related Factor 2
- NFE2L2 protein, human
- RNA, Messenger
- Sulfides
- Glutathione Peroxidase
- Superoxide Dismutase
- Sulfurtransferases
- 3-mercaptopyruvate sulphurtransferase
- Cystathionine beta-Synthase
- Cystathionine gamma-Lyase
- Hydrogen Sulfide
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Topics |
- Aged
- Amputation, Surgical
- Biomarkers
(analysis)
- Cystathionine beta-Synthase
(genetics, metabolism)
- Cystathionine gamma-Lyase
(genetics, metabolism)
- Female
- Glutathione Peroxidase
(metabolism)
- Humans
- Hydrogen Sulfide
(analysis)
- Ischemia
(surgery)
- Leg
(blood supply, surgery)
- Male
- Muscle, Skeletal
(metabolism)
- NF-E2-Related Factor 2
(metabolism)
- Oxidative Stress
(genetics)
- RNA, Messenger
- Signal Transduction
(genetics)
- Sulfides
(analysis)
- Sulfurtransferases
(genetics, metabolism)
- Superoxide Dismutase
(metabolism)
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