Abstract |
Intravenous immunoglobulin [ IVIg], plasma exchange [PE], and corticosteroids are efficacious treatment in chronic inflammatory demyelinating polyneuropathy [ CIDP]. IVIg is effective in multifocal motor neuropathy [MMN]. NIS, NIS-weakness, sum scores of raw amplitudes of motor fiber (CMAPs) amplitudes, and Dyck/Rankin score provided reliable measures to detect and scale abnormality and reflect change; they are therefore ideal for office management of response-based immunotherapy (R-IRx) of CIDP. Using efficacious R-IRx, a large early and late therapeutic response (≥ one-fourth were in remission or had recovered) was demonstrated in CIDP. In MMN only an early improvement with late non-significant worsening was observed. The difference in immunotherapy response supports a fundamental difference between CIDP (immune attack on Schwann cells and myelin) and MMN (attack on nodes of Ranvier and axons).
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Authors | Peter J Dyck, Bruce V Taylor, Jenny L Davies, Michelle L Mauermann, William J Litchy, Christopher J Klein, P James B Dyck |
Journal | Muscle & nerve
(Muscle Nerve)
Vol. 52
Issue 4
Pg. 488-97
(Oct 2015)
ISSN: 1097-4598 [Electronic] United States |
PMID | 25976871
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
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Copyright | © 2015 Wiley Periodicals, Inc. |
Chemical References |
- Adrenal Cortex Hormones
- Immunoglobulins, Intravenous
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Topics |
- Action Potentials
- Adrenal Cortex Hormones
(therapeutic use)
- Electromyography
- Female
- Humans
- Immunoglobulins, Intravenous
- Immunotherapy
(methods)
- Male
- Neural Conduction
(physiology)
- Neuromuscular Diseases
(immunology, physiopathology, therapy)
- Plasma Exchange
(methods)
- Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
(immunology, physiopathology, therapy)
- Retrospective Studies
- Severity of Illness Index
- Treatment Outcome
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