Abstract | BACKGROUNDS: METHODS: This randomized, open-label, controlled trial was conducted on 60 neonates born to illicit drugs dependent mothers at Vali-Asr and Akbar-Abadi hospitals, Tehran, Iran, who exhibited NAS requiring medical therapy. The neonates were randomized to receive either: Oral Morphine Sulfate or a loading dose of Phenobarbital followed by a tapering dose. The duration of treatment required for NAS resolution, the total hospital stay and the requirement for additional second line treatment were compared between the treatment groups. RESULTS: CONCLUSIONS: TRIAL REGISTRATION: This study is registered at the Iranian Registry of Clinical Trials ( www.irct.ir ) which is a Primary Registry in the WHO Registry Network. (Registration Number = IRCT201406239568N8 ).
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Authors | Fatemeh Nayeri, Mahdi Sheikh, Majid Kalani, Pedram Niknafs, Mamak Shariat, Hosein Dalili, Ahmad-Reza Dehpour |
Journal | BMC pediatrics
(BMC Pediatr)
Vol. 15
Pg. 57
(May 15 2015)
ISSN: 1471-2431 [Electronic] England |
PMID | 25976238
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics, Opioid
- Hypnotics and Sedatives
- Morphine
- Phenobarbital
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Topics |
- Administration, Oral
- Analgesics, Opioid
(therapeutic use)
- Chemotherapy, Adjuvant
- Drug Administration Schedule
- Humans
- Hypnotics and Sedatives
(therapeutic use)
- Infant, Newborn
- Iran
- Length of Stay
- Morphine
(therapeutic use)
- Neonatal Abstinence Syndrome
(drug therapy)
- Phenobarbital
(therapeutic use)
- Prospective Studies
- Treatment Outcome
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